Miniaturization is defined as the creation of ever-smaller scales for mechanical, optical, and electronic products and devices. It is continuing trend in the production of technology. We have interst in the miniaturization of the achiral and chiral bioanalytical process where functional integration of many complex tasks are combined into a simple device fabricated on the nano and micro-format. The aim of this process is to reduce sample requirements, time expenditure, cost, reagent and energy consumption.