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Lipase-catalysis in non-standard organic solvents


Over the last few years, there has been a dramatic increase in the number of publications in the field of lipase-catalyzed reactions performed in common standard organic solvents. A fairly large percentage of these publications have emerged from organic chemists who have recognized the potential of Biocatalysis as a viable and popular technique in organic synthesis, specially in the production of homochiral molecules and pharmaceutical compounds.
We have published many papers in this field and we continue to explore modern kinetic resolution on the miniaturization level using micro-reactors and new chiral stationary phase for the high-throughput screening of the enantioselectivity of tested enzymes.

M. Ahmed, T. Kelly and A. Ghanem, Tetrahedron 2012, 68, 6781-6802

A. Ghanem, J. Chromatogr. A, 2010, 1217, 1063-1074.  

A. Ghanem, Chirality, 2010, 22, 597–603.

A. Ghanem, V. Schurig, Chirality 2001,13:118-123.

A. Ghanem, V. Schurig, Tetrahedron: Asymmetry 2001, 12/19, 2761-2766.

A. Ghanem “Lipase-catalyzed kinetic resolution of racemates: A versatile method for the separation of enantiomers” in "Enantiomer Separation Fundamentals and Practical Methods" edited by Fumio Toda. ISBN 1-4020-2336-7, 2006., Kluwer Academic Publishers, The Netherlands 

Copyright 2013, A. Ghanem