Monolithic silica columns have shown to have
superior performance as compared to particle packed columns. They afford fast analysis
by bypassing the limitations imposed by pressure via the through-pores, which allow higher flow rates than particulate columns
at reasonable column backpressures. Analyte capacity is usually provided within the monolithic structure by the smaller mesopores.
Our interests lie in the preparation of achiral
and chiral hybrid micro-sized silica monoliths with superior performance for multi-mode application in achiral and chiral micro-HPLC.
1. A. Ghanem and T. Ikegami “Recent advances
in silica monolith” J. Sep. Sci. 2011, 34, 1945–1957.
2. A. Ghanem, T. Ikegami, N. Tanaka “New
Silica Monolith Bonded Chiral (R)-γ Butyrolactone for Enantioselective Micro High-Performance Liquid Chromatography”
Chirality 2011, 23 (10) 887-890.