Link to Research Gate/Publications Dr Ashraf Ghanem
Ten career-best publications 1. Ashraf Ghanem, “The utility
of cyclodextrins in lipase-catalyzed transesterification in organic solvents: enhanced reaction rate and enantioselectivity”
Org. Biomol. Chem (former Perkin 1 and Perkin 2). 1 (2003) 1282-1291. (ERA: *A; IF 3.5;
ranking: 10/55 in Organic Chemistry). The first report on the use of macrocyclic additives to enhance the reaction rate
and enantioselectivity in lipase-catalyzed reactions in organic solvents showing strong evidences of enzyme morphology alterations.
2. Paul Muller and Ashraf Ghanem
“Rhodium (II) catalyzed asymmetric cyclopropanation with dimethyl malonate”
Org. Letter, 6(23) pp 4347 – 4350, 2004. (ERA:*A; IF 5.1; ranking: 4/55 in Organic Chemistry. The
first discovery of a new chiral dirhodium catalyst with extraordinary enantioselectivity. The impact of such a discovery has
been reported by others (eg. Charette Angew. Chem. Int. Ed. 2008, 47, 10155)
3. Ashraf Ghanem “Lipase-catalyzed
kinetic resolution of racemates: A versatile method for the separation of enantiomers” Chapter (7) contribution in "Enantiomer
Separation Fundamentals and Practical Methods" edited by Fumio Toda, Japan. Springer Verlag Publishers, New York 2005
and 2006 Ed. ISBN 1-4020-2336-7 and 9781402023361. This book has been reviewed by Amazon.com as being an “invaluable
resource” for “Chemists, Engineers and students working in the field of chiral compounds in Universities, Institutes
and Industry”.
4. Ashraf Ghanem ‘A C-11 Chiralsil-dex for enantioselective
chromatographic analysis of cyclopropane derivatives” Talanta 66 (2005) 1234-1241. (ERA: *A; IF 3.2; ranking: 10/70
in Analytical Chemistry). A new chiral GC phase that separated “difficult to resolve” pharmaceutical ingredients
for industrial application. The developed method provides direct information about reaction parameters and avoids time-consuming
work-up procedures. 5. Ashraf
Ghanem, L. Naim, “Immobilized versus coated amylose tris-(3,5-dimethylphenylcarbamate)
chiral stationary phases for the enantioselective separation of cyclopropane derivatives by liquid chromatography. J. Chromatogr.
A, 1101 (2006) 171-178. (ERA: *A; IF 3.7; ranking: 6/70 in Analytical Chemistry). It shows the impact of
immobilization on the enantioselective resolution of cyclopropane derivatives. 6. A.
Ghanem “True and False reversal of elution order of barbiturates on a bonded cellulose-based chiral stationary
phase” J. Chromatogr. A 1132 (1-2) (2006) 329-332. (ERA: *A; IF 3.7; ranking: 6/70 in Analytical Chemistry).
A unique report on the existence of true and false reversal of elution order of enantiomers based on polarimetric response
when different mobile phases are compared on the same CSP. 7.
A. Ghanem, H. Hoenen, H.Y. Aboul-Enein “Application and comparison of immobilized and coated amylose
tris-(3,5-dimethylphenylcarbamate) chiral stationary phases for the enantioselective separation of b -blockers enantiomers
by liquid chromatography” Talanta 68(3), (2006), 602-609. . (ERA: *A; IF 3.2; ranking: 10/70 in Analytical
Chemistry). It shows strong evidences about the advantages and disadvantages of the immobilization of chiral stationary
phases and its impact on the resolution of enantiomers.
8. A.
Ghanem “Trends in lipase-catalyzed asymmetric access to enantiomerically pure/enriched compounds” Tetrahedron
63 (2007) 1721-1754. (ERA: A; IF 2.9; ranking: 16/55 in Organic Chemistry). This work summarizes my effort over ten
years of research working in the field of biocatalysis and chiral analysis to access enantiomerically pure/enriched compounds.
9. Ashraf Ghanem “Lipase-catalyzed
kinetic resolution of acidic drugs” J. Chromatogr. A, 1217 (7) (2010) 1063-1074. (ERA: *A; IF 3.7; ranking: 6/70
in Analytical Chemistry). This is the first report showing direct/online monitoring of lipase-catalyzed kinetic resolution
of acidic drugs in non-standard organic solvents which has a direct impact on monitoring and access to pure drugs in the pharmaceutical
industry. 10. Ashraf
Ghanem, Michael G. Gardiner, Paul Müller, and Rachel M. Williamson “First X-ray Structure of a N-Naphthaloyl
tethered chiral dirhodium(II) complex: structural basis for tether substitution improving asymmetric control in olefin cyclopropanation
demonstrated in a one-pot process with in situ generated phenyliodonium ylides. Chemistry: A European Journal, 16
(2010) 3291-3295. (ERA: *A; IF 5.4; ranking: 12/127 in Chemistry multidisciplinary). This is the first X-ray of our
N-naphthaloyl tethered chiral dirhodium(II) complex showing a chiral square conformation that represents a milestone in understanding
the mechanism of asymmetric cyclopropanation of olefins.
All Publications: 70 (> 2200 citations) H index = 24 1. Ashraf Ghanem and Volker Schurig.”Lipase-catalysed transesterification of 1-(2-furyl)ethanol
using isopropenylacetate” Chirality 13:118-123, 2001. (ERA: B; IF 2.2; ranking: 25/70 in Analytical Chemistry)
2. Ashraf Ghanem and Volker Schurig.”Per-acetylated
b-Cyclodextrin as additive in enzymatic reactions: enhanced reaction rate and enantiomeric ratio in lipase-catalyzed
transesterifications in organic solvents. Tetrahedron: Asymmetry
vol. 12/19 pp 2761-2766. 2001. (ERA: B; IF 2.8; ranking: 17/55 in Organic Chemistry)
3. Ashraf Ghanem
and Volker Schurig. “Lipase-catalyzed access to enantiomerically pure (R)- and (S)-trans-4-phenyl-3-butene-2-ol”
Tetrahedron: Asymmetry vol. 14/1 pp. 57-62. 2003. (ERA: B; IF 2.8; ranking: 17/55 in Organic Chemistry) 4. Ekkehard
Lindner, Ashraf Ghanem, Ismail Warad, Klaus Eichele, Hermann Mayer, Volker Schurig. “Asymmetric hydrogenation of an a,b-unsaturated ketone by diamine(ether-phosphine)ruthenium(II)
complexes and lipase-catalyzed kinetic resolution: a consecutive approach” Tetrahedron:
Asymmetry vol. 14/8 pp. 1045-1053, 2003. (ERA: B; IF 2.8; ranking: 17/55 in Organic Chemistry) 5. Ashraf
Ghanem, Charlotte Ginatta, Zhengjin Jian, Volker Schurig. “Chirasil-b-dex with a new C11-spacer for enantioselective
gas chromatography. Application to the kinetic resolution secondary alcohols catalyzed by Lipase” Chromatographia, Vol 57, S-275, 2003.. (ERA: B; IF 1.3; ranking: 44/70 in Analytical Chemistry) 6. Ashraf Ghanem.
“The utility of cyclodextrins, sol-gel procedure and gas chromatography in lipase-mediated enantioselective catalysis:
kinetic resolution of secondary alcohols“ PhD Thesis, University of Tübingen,
Germany, 2002.
7. Ashraf Ghanem. “The
utility of cyclodextrins in lipase-catalyzed transesterification in organic solvents: enhanced reaction rate and enantioselectivity
Organic & Biomolecular Chemistry (former Perkin 1 and Perkin
2) Org. Biomol. Chem. 1, 1282-1291, 2003. (ERA: *A;
IF 3.5; ranking: 10/55 in Organic Chemistry) 8. Ashraf Ghanem
and Volker Schurig. “Entrapment of Pseudomonas cepacia lipase with peracetylated b-cyclodextrin in sol-gel:
application to the kinetic resolution of secondary alcohols” Tetrahedron:
Asymmetry, Vol. 14(17), pp. 2547-2555, 2003. (ERA: B; IF 2.8; ranking: 17/55 in Organic Chemistry)
9. Ashraf
Ghanem and Volker Schurig. “Lipase-catalyzed transesetrification of secondary alcohols
using isopropenyl acetate as acyl donor in organic solvents” Monatshefte für
Chemie/Chemical monthly, 134, 1151-1157, 2003. (ERA: B; IF 1.4; ranking: 57/127 in Chemistry multidisciplinary)
10. Paul Müller and Ashraf Ghanem.
“Catalytic cyclopropanation of olefins using new in situ generated phenyliodonium ylide derived from Meldrum´s
acid” Synlett, 12,
1930-1833, 2003. (ERA: A; IF 2.7; ranking: 18/55 in Organic
Chemistry) 11. Ashraf Ghanem “Lipase-catalyzed
kinetic resolution of racemates: A versatile method for the separation of enantiomers” Chapter contribution in a book
edited by Prof. Fumio Toda, Japan (Chapter 7). "Enantiomer
Separation Fundamentals and Practical Methods " ISBN 1-4020-2336-7, 2006.
Kluwer Academic Publishers, The Netherlands. 12. Paul Muller and Ashraf Ghanem “Rhodium (II)
catalyzed asymmetric cyclopropanation with dimethyl malonate” Org. Letter,
6(23) pp 4347 – 4350, 2004. (ERA:*A; IF 5.1; ranking:
4/55 in Organic Chemistry)
13. Ashraf Ghanem, Hassan Y Aboul-Enein. Lipase-mediated chiral resolution of racemates in organic
solvents. Tetrahedron: Asymmetry 2004, 15/21
pp. 3331-3351. (ERA: B; IF 2.8; ranking: 17/55 in Organic Chemistry)
14. Ashraf Ghanem, Hassan Y. Aboul-Enein, Fabienne Lacrampe, Jiang Zhengjin, Stefan Grass,
Paul Müller. “Enantioselective Gas Chromatographic Analysis
of Cyclopropane Derivatives” Chromatographia, 3-4, 103-11, 2005. (ERA: B; IF 1.3; ranking: 44/70 in Analytical Chemistry)
15. Ashraf Ghanem, Hassan Y Aboul-Enein, Paul Muller “One pot synthesis and chiral analysis
of cyclopropane derivatives” Chirality, 17:44-50, 2005. (ERA: B; IF 2.2; ranking: 25/70 in Analytical Chemistry)
16. Ashraf Ghanem, Fabienne Lacrampe and Volker Schurig. “Rhodium(II)-catalyzed inter-
and intramolecular cylopropanation using diazo compounds and phenyl iodonium ylides: Synthesis and Chiral analysis. Helvetica Chimica Acta, vol. 88, issue 2, pp 216-239, 2005. (ERA: B; IF 1.4; ranking: 59/127 in Chemistry multidisciplinary)
17. Hassan. Y. Aboul-Enein, Ashraf Ghanem and Hubert Hoenen. "Determination
of Vardenafil in Pharmaceutical Formulation by HPLC Using a Conventional C18 and Monolithic Silica Columns" Journal of Liquid Chromatography and Related
Technologies, 28:593-604. 2005. (ERA: C; IF
1; ranking: 50/70 in Analytical Chemistry)
18. Ashraf
Ghanem, Hubert Hoenen, Paul Müller and Hassan Y. Aboul-Enein. ‘Enantiomeric separation of cyclopropane
derivatives on a polysaccharide-based chiral stationary phase’ Analytica Chimica
Acta, 538/1-2, pp. 15-24, 2005. (ERA: A; IF
3.1; ranking: 12/70 in Analytical Chemistry)
19. Ashraf
Ghanem ‘A C-11 Chiralsil-dex for enantioselective chromatographic analysis of cyclopropane derivatives, Talanta, 2005, 66, 1234-1241. (ERA: *A; IF 3.2; ranking: 10/70 in Analytical
Chemistry)
20. Ashraf Ghanem, Fabienne Lacrampe, Hassan Y. Aboul-Enein, and Volker Schurig ’Diazo Compounds and Phenyliodonium
Ylides in the Inter- and Intramolecular Cyclopropanations Catalyzed by Dirhodium (II): Synthesis and Chiral Resolution by
GC versus HPLC’ Montshefte Fur Chemie: Chemical Monthly 2005,
136, 1205-1219. (ERA: B; IF 1.4; ranking: 57/127 in Chemistry multidisciplinary)
21. Hassan Y. Aboul-Enein, Hubert Hoenen, Ashraf Ghanem and Michael
Koll. ’Reversed phase liquid chromatographic method for the high-throughput analysis of clopidogrel in pharmaceutical
formulations using a monolithic silica column. Journal of Liquid Chromatography
and Related Technologies, 28/9; 1357-1365, 2005. (ERA: C; IF 1; ranking: 50/70 in Analytical Chemistry)
22. Ashraf Ghanem, Hassan Y Aboul-Enein. “Applications of lipases in kinetic resolution
of racemates” Chirality 17: 1-15, 2005. (ERA: B; IF 2.2; ranking: 25/70 in Analytical Chemistry)
23. Jacek Bojarski, Hassan Y. Aboul-Enein and Ashraf Ghanem. "What's
new in chromatographic enantioseparation" Current
Analytical Chemistry, 1, 59-77, 2005. (ERA: C; IF 1.9; ranking: 37/70 in Analytical Chemistry)
24. Imran Ali, Hassan Y. Aboul-Enein and Ashraf Ghanem" Enantioselective
toxicities and carcinogenesis" Current Pharmaceutical Analysis" 1, 109-125, 2005. (ERA:
C; IF 1; ranking: 38/70 in Analytical Chemistry)
25. Ashraf
Ghanem “Lipase in Organic Synthesis” An invited Chapter in “ Encyclopedia of Reagents in Organic
Synthesis” edited by Prof. L. Paquette, P. Fuchs, D. Crich and P. Wipf. John Wiley & Sons, United Kingdom, 2006.
26. Ashraf
Ghanem “On the occasion of Prof. Schurig’s
65th birthday” Chromatographia 61, 101, 2005. (ERA: B; IF 1.3; ranking: 44/70 in Analytical Chemistry)
27. Ashraf Ghanem and Hassan Y. Aboul-Enein.“ Comparison, applications, advantages and
limitations of immobilized and coated amylose tris-(3,5-dimethylphenylcarbamate) chiral stationary phases in high-performance
liquid chromatography” Journal of liquid chromatography and related technology,
2005, 28: 2669-2680. (ERA: C; IF 1; ranking: 50/70 in Analytical Chemistry)
28. Ashraf Ghanem and Hassan Y. Aboul-Enein.
“On the solvent versatility in immobilized amylose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase in high
performance liquid chromatography : application to the asymmetric cyclopropanation of olefins. Analytica Chimica Acta, 2005, Volume 548, Issues 1-2, Pages 26-32. (ERA: A; IF 3.1; ranking: 12/70
in Analytical Chemistry)
29. Ashraf Ghanem and
Lahoucine Naim “Immobilized versus coated amylose tris-(3,5-dimethylphenylcarbamate) chiral
stationary phases for the enantioselective separation of cyclopropane derivatives by liquid chromatography. Journal of Chromatography A, 2006,
Vol. 1101, Issues 1-2, Pages 171-178. (ERA: *A; IF 3.7; ranking: 6/70 in Analytical Chemistry)
30. Ashraf Ghanem, Hubert Hoenen, and Hassan Y. Aboul-Enein. “Application and comparison
of immobilized and coated amylose tris-(3,5-dimethylphenylcarbamate) chiral stationary phases for the enantioselective
separation of b-blockers enantiomers by high-performance liquid chromatography” Talanta
2006, 68, 602-609. (ERA: *A; IF 3.2; ranking: 10/70 in Analytical Chemistry)
31. Imran Ali, Naim Lahoucine, Ashraf Ghanem, Hassan Y. Aboul-Enein. Chiral
separation of Piperidine-2,6-dione analogues on Chiralpak IA and Chiralpak IB columns using HPLC, Talanta 2006, Vol. 69,
Issue 4, Pages 1013-1017. (ERA: *A; IF 3.2; ranking: 10/70 in Analytical Chemistry)
32. Paul Muller, Yves F. Allenbach, Sabrina Chappellet, Ashraf Ghanem “Asymmetric
cyclopropanations and cycloadditions of dioxocarbenes” Synthesis 2006,
10, 1689-1696. (ERA:B; IF 2.5; ranking: 23/50 in Organic Chemistry)
33. Ashraf Ghanem “Trends in lipase-catalyzed asymmetric access to enantiomerically
pure/enriched compounds” Tetrahedron 2007, 63, Pages 1721-1754.
(ERA:A; IF 2.9; ranking: 16/50 in Organic Chemistry) Cheminform 2007,
Volume
38, Issue 21.
34. Ashraf Ghanem “True and False reversal of elution order of barbiturates
on a bonded cellulose-based chiral stationary phase” Journal of Chromatography
A 2006, Volume 1132, Issues 1-2, pages 329-332. . (ERA: *A; IF 3.7; ranking: 6/70 in Analytical
Chemistry)
35. Ashraf Ghanem “Exploring
solvent versatility in bonded cellulose-based chiral stationary phase for the enantioselective liquid chromatographic resolution
of racemates” Journal of Separation Science 2007, 30(7), 1019-1028.
(ERA: B; IF 2.7; ranking: 17/70 in Analytical Chemistry) 36. Ashraf Ghanem “Application
of C-11 Chirasil-dex in enantioselective separation of barbiturates” Analytical
Chemistry Insights 2007, 2, 75–80.
37. Ashraf Ghanem, Ebtessam Al-Humaidi “Chiral recognition ability and
solvent versatility of bonded amylose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase: enantioselective liquid
chromatographic resolution of racemic N-alkylated barbiturates and thalidomide analogs” Chirality 2007, 19(6), 477-484. (ERA: B; IF 2.2; ranking: 25/70 in Analytical Chemistry)
38. Ashraf Ghanem, Farrag El-Behairy, Mohammed Al-Ahdal “Direct enantioslective
HPLC monitoring of lipase-catalyzed kinetic resolution of racemates in non-standard organic solvents” Chromatographia 2007, 65(11/12), 681-686. (ERA: B; IF 1.3; ranking: 44/70
in Analytical Chemistry)
39. Ashraf Ghanem,
Mohammed Al-Ahdal, Mohammed Nabil Aboul-Enein, Aida El-Azzouny, Mohammed El-Behairy,Kamilia
Amin “ Direct enantioselective HPLC monitoring of lipase-catalyzed kinetic resolution of tiaprofenic acid in non-standard
organic solvents” Chirality 2008, 20 (8) 871-877. (ERA: B; IF 2.2; ranking: 25/70 in Analytical Chemistry)
40. A. Ghanem “Prof. Paul Haddad's 60th birthday” Chromatographia 2008, 68, 883-884.
41. Kenneth C. Saunders, Ashraf Ghanem, Hon Wei Boon, Emily F. Hilder, and Paul
R. Haddad “Bioanalysis using monolithic phases: Challenges, recent developments and future possibilities” Analytica Chimica Acta, 2009, 652, 22-31. (ERA: A; IF 3.1; ranking:
12/70 in Analytical Chemistry)
42. Ashraf Ghanem, Hon
Wei Boon, Kenneth C. Saunders, Emily F. Hilder, and Paul R. Haddad, “In situ Preparation of Robust Porous Modified Sulfopropyl
Methacrylate Polymer-based Monolithic Capillary for mHPLC Analysis”
draft completed, internal revision.
43. Ashraf
Ghanem “On the Solvents Versatility of Immobilized Amylose and Cellulose-based Chiral Stationary Phases in
Enantioselective LC Separation and Monitoring of Bio-catalyzed Resolutions of Acidic Drugs in Non-Standard Organic Solvents”
Chromatographia 2009, Volume 70, Issue 3, Page 349. (ERA: B; IF 1.3; ranking: 44/70 in Analytical Chemistry)
44. Ashraf Ghanem “Lipase-catalyzed enantioselective access to flurbiprofen” Chirality 2010, Volume 22, Issue 6, June 2010, Pages: 597–603. (ERA:
B; IF 2.2; ranking: 25/70 in Analytical Chemistry)
45. Ashraf
Ghanem “Lipase-catalyzed kinetic resolution of acidic drugs” Journal
of Chromatography A, 2010, Volume 1217, 1063-1074.
ERA: *A; IF 3.7; ranking: 6/70 in Analytical Chemistry)
46. Ashraf
Ghanem, Michael G. Gardiner, Paul Müller, and Rachel M. Williamson “First X-ray Structure of a N-Naphthaloyl
Tethered Chiral Dirhodium(II) Complex: Structural Basis for Tether Substitution Improving Asymmetric Control in Olefin Cyclopropanation
Demonstrated in a One-Pot Process with in situ Generated Phenyliodonium Ylides: Chemistry: A European Journal, 16 (2010) 3291-3295. (ERA: *A; IF 5.4; ranking: 12/127 in Chemistry
multidisciplinary)
47. Michael G. Gardiner
and Ashraf Ghanem “Enantioselectivity control with the chiral dirhodium(II) complex Rh2(S-PTTL)4:
New insights on the conformational flexibility of the N-phthaloyl units in the crown cavity, 2010, unpublished results.
48. Michael
G. Gardiner, Ashraf Ghanem, and Rachel M. Williamson. “ Axial ligand structural effects for
flexible chiral N-phthaloyl protected amino acid-based tetracarboxylate dirhodium(II) complexes: X-ray crystal structures
of three new conformers of [Rh2(S-PTPA)4] 2010, unpublished results. 49. Ghanem, A., and Ikegami,
T., (2011). “Recent advances in silica monolith” J. Sep. Sci. 2011, 34, 1945–1957.
50. Ghanem, A., Ikegami, T., Tanaka, N. (2011). “New
Silica Monolith Bonded Chiral (R)-γ Butyrolactone for Enantioselective Micro High-Performance Liquid Chromatography”
Chirality 2011, 23 (10) 887-890. 51. Mattiza, J.T., Duddeck,
H., Gardiner, M.G., Patrovic, A., Berova, N., and Ghanem, A. (2011). “Optimizing
dirhodium(II) tetrakiscarboxylates as chiral NMR auxiliaries “Org. Biomol. Chem. (2011) 9, 6542. 52. M. Ahmed, T. Kelly and A. Ghanem “Enzymes
in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemisation Reactions Tetrahedron 2012, Volume 68, Issue 34, 26
August 2012, Pages 6781-6802. 53. M.
El-Deftar and A. Ghanem “Dirhodium catalysis: future opportunities in enantioselective access to enantiomerically
pure compounds” Current Organic Chemistry (2012) 16, 1808-1836 54. Ashraf
Ghanem, Robert Healey, Frady Gouany. “Recent trends in Plasmid DNA-based Vaccines’ separations“ Anal. Chim. Acta, (2013) 760, 1-15 (Cover of the
first volume in 2013) 55. R. Healey and A. Ghanem “Chiral silica monolith for Pharmaceutical
Application, Chirality (2013), 25, 6, 314-323. (ERA: B; IF 2.67; ranking: 25/70 in Analytical Chemistry). 56. Ahmed
M, Ghanem A. Chiral β-cyclodextrin functionalized polymer monolith for the direct enantioselective reversed phase nano
liquid chromatographic separation of racemic pharmaceuticals. J. Chromatogr. A 2014;1345(0):115-127. 57.
Ahmed M, Ghanem A. Enantioselective nano liquid chromatographic separation of racemic pharmaceuticals: a facile one-pot in
situ preparation of lipase-based polymer monoliths in capillary format. Chirality In press, DOI 10.1002/chir.22290. 58. M.G. Gardiner,
A. Ghanem, R.M. Williamson, A. Petrovic, N. Berova“ Axial ligand structural effects for flexible chiral N-phthaloyl
protected amino acid-based tetracarboxylate dirhodium(II) complexes: X-ray crystal structures of three new conformers of [Rh2(S-PTPA)4]“ in
revision. 59. Frday Gouany, Ashraf Ghanem “Chiral Dirhodium(II)
Carboxylates and Carboxamidates as Effective Chemzymes in Asymmetric Synthesis of Three-Membered Carbocycles” Chirality
2014 in press 60. Frady Gouany, Johncarlo Maddalena,
Ashraf Ghanem “Rh2(S-1,2-NTTL)4: A Novel Rh2(S-PTTL)4 Analog With Lower Ligand Symmetry for Asymmetric Synthesis of
Chiral Cyclopropylphosphonates” Chirality
2014, In press.
Posters and Conferences (27)
1. Ashraf Ghanem and Volker Schurig.”Lipase-catalysed transesterification of 1-(2-furyl) ethanol using isopropenylacetate”
Chirality, Chamonix, France 2000. 2. Ashraf
Ghanem and Volker Schurig.”Per-acetylated b-Cyclodextrin as additive in enzymatic reactions: enhanced
reaction rate and enantiomeric ratio in lipase-catalyzed transesterifications in organic solvents. Second European catalysis symposium, Pisa/Italy, Sept. 2001. 3. Ashraf Ghanem.
“The utility of cyclodextrins in lipase-catalyzed transesterification in organic solvents: enhanced reaction rate and
enantioselectivity Second European Catalysis Symposium, Pisa/Italy, Sept.2001. 4. Ashraf Ghanem and G. H.
El-Gemeii. “Enzyme-Catalyzed Kinetic Resolution of 2-Benzoyloxy-2-(o-Bromophenyl) acetonitrile” Chirality, Orlando/USA 2001. 5. Ashraf
Ghanem and Volker Schurig.”Cyclodextrins as additives in enzymatic reactions: enhanced reaction rate and enantiomeric
ratio in lipase-catalyzed transesterifications in organic solvents. Chirality 2002
Hamburg, Germany.
6. Ashraf Ghanem
and Volker Schurig. “Lipase-catalyzed access to enantiomerically pure (R)- and (S)-trans-4-phenyl-3-butene-2-ol”
Chirality 2002 Hamburg, Germany. 7. Ekkehard Lindner, Ashraf
Ghanem, Ismail Warad, Klaus Eichele, Hermann Mayer, Volker Schurig. “Asymmetric
hydrogenation of an a,b-unsaturated ketone
by diamine (ether-phosphine)ruthenium(II) complexes and lipase-catalyzed kinetic resolution: a consecutive approach”
Chirality 2002 Hamburg, Germany. 8. Ashraf Ghanem, Charlotte Ginatta, Zhengjin Jian,
Volker Schurig. “Chirasil-b-dex with a new C11-spacer for enantioselective
gas chromatography. Application to the kinetic resolution secondary alcohols catalyzed by Lipase” Chirality 2002 Hamburg, Germany. 9. Ashraf Ghanem and Volker Schurig.”Large scale production
of 1-(2-furyl) ethanol by lipase-catalysed transesterification. Chirality
2002 Hamburg, Germany.
10. Paul Müller and Ashraf Ghanem. "Catalytic
asymmetric cyclopropanation of olefins with new in situ generated phenyliodonium ylide". Swiss Chemical Society meeting, Lausanne 2003. 11. Paul Müller and Ashraf Ghanem."Asymmetric Cyclopropanation of olefins
using a New in situ Generated Phenyliodonium Ylide". Younger European
Chemist´s conference: Grenoble, France, 2003.
12. Paul Müller and Ashraf Ghanem. "Rhodium (II)-catalyzed asymmetric cyclopropanation of olefins". Chemistry Day, Champery 2003, Switzerland. 13. Ashraf Ghanem, Hassan Y. Aboul-Enein, Fabienne Lacrampe, Jiang Zhengjin, Paul
Müller and Volker Schurig “Enantioselective
Gas Chromatographic Analysis of Cyclopropane Derivatives” Chirality, July
11-14, 2004, New York, NY, USA.
14. Ashraf Ghanem
and Paul Muller ‘Asymmetric Cyclopropanation of Olefins using a New in situ Generated Phenyliodonium Ylide:
One Pot Synthesis and Chiral Analysis, Chirality, July 11-14, 2004, New York, NY,
USA. 15. Ashraf Ghanem and Paul Muller. “Synthesis and Evaluation of Novel Dirhodium (II) Carboxylate
Catalysts: Application to The Asymmetric Access to Cyclopropanes” Chirality,
July 11-14, 2004, New York, NY, USA.
16. Ashraf Ghanem, Hassan Y. Aboul-Enein, and Volker Schurig “Entrapment
of Pseudomonas cepacia lipase with peracetylated b-cyclodextrin in sol-gel: Application to the kinetic resolution
of secondary alcohols, Chirality, July 11-14, 2004, New York, NY, USA.
17. Ashraf Ghanem and
Hassan Y. Aboul-Enein „Chiral dirhodium (II)-catalyzed enantioselective access to cyclopropane derivatives“
International symposium for Chineese Organic Chemistry, 18-12 December 2004, Hong
Kong. Poster Nr 191.
18. Ashraf Ghanem, “Enantioselective
GC and HPLC Analysis of Cyclopropane Derivatives” Chirality 2005, 11-14 Sept. 2005, Parma, Italy.
19. Ashraf Ghanem,
Lahoucine Naim and G. J. De Jong, Immobilized versus coated cellulose tris-(3,5-dimethylphenylcarbamate)
chiral stationary phases for the enantioselective separation of cyclopropane derivatives by liquid chromatography, Chirality 2005, 11-14 Sept. 2005, Parma, Italy.
20.
Ashraf Ghanem, Lahoucine Naim, Hassan Y. Aboul-Enein : On the solvent versatility in immobilized amylose
tris-(3,5-dimethylphenylcarbamate) chiral stationary phase in high-performance liquid chromatography: application to the asymmetric
cyclopropanation of olefins, Chirality 2005, 11-14 Sept. 2005, Parma, Italy.
21. Ashraf Ghanem “Enantioslective analysis of cyclopropanes
derivatives” The 9th International Pharmaceutical Sciences Conferences and Exposition, December 17-21,
2005, Riyadh, Saudi Arabia.
22.
Ashraf Ghanem “Online HPLC monitoring of biocatalyzed transesetrification of benzbromaron metabolite
in non-standrad solvents: application to immobilized cellulose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase
(Chiralpak IB)”, poster 158 at the 56th Canadian Chemical
Engineering Conference, October 15-18, 2006, Sherbrooke, CANADA.
23.
Ashraf Ghanem “Towards the synthesis of anti-cancer drugs: chiral dirhodium (II) catalyzed asymmetric
cyclopropanation of olefins using a new in situ generated phenyliodonium ylides: one pot synthesis and chiral analysis” poster
159 at the 56th Canadian Chemical Engineering Conference, October 15-18,
2006, Sherbrooke, CANADA. 24. Ashraf Ghanem “On
the solvent versatility in immobilized amylase tris-(3,5-dimethylphenylcarbamate) chiral stationary phase in high performance
liquid chromatography: application to the asymmetric cyclopropanation of olefins” poster 335 at the 56th Canadian Chemical Engineering Conference, October 15-18, 2006, Sherbrooke, CANADA.
25. Ashraf Ghanem “Enantioselective GC and
HPLC analysis of cyclopropane derivatives” poster 336 at the 56th
Canadian Chemical Engineering Conference, October 15-18, 2006, Sherbrooke, CANADA. 26. Ashraf Ghanem “Lipase-catalyzed
kinetic resolution of acidic drugs” HPLC 2007, Ghent, Belgium.
27. Ashraf Ghanem “On the solvent versatility of Chiralpak IA, IB and IC” Canadian
Chemistry conference, 2007, Winnipeg, Canada. 28. Ashraf Ghanem “Preparation of Reversed-phase And Cation-exchange
Mixed-mode Porous Sulfopropyl Methacrylate Polymer-based Monolithic Capillary for the Separation Of Pharmaceutical Compounds
Using Capillary-Liquid Chromatography” ASASS (ACROSS Symposium on Advances in Separation Science), Tasmania
Australia, Dec 2008. 29. Ashraf Ghanem ”Kinetic
resolution of acidic drugs” ASASS (ACROSS Symposium on Advances in Separation Science), Tasmania Australia,
Dec 2008. 30. Ashraf Ghanem ”In situ Preparation of Robust Porous Modified Mixed-mode Sulfopropyl
Methacrylate Monolithic Capillary for mHPLC Analysis of Pharmaceutical Compounds” Abstract and Poster for HPLC
conference in Dresden, Germany, Jun 2009. 31. Ashraf Ghanem “Direct HPLC monitoring of lipase-catalyzed kinetic resolution
of acidic/anti-inflammatory drugs in non-standard organic solvents” Chirality July 2010 Sapporo, Japan. 32. Ashraf Ghanem “Chiral Square Conformation of Rh2(nttl)4: Asymmetric
Cyclopropanation of olefins via in situ generated phenyliodonium ylides” Chirality July 2010, Sapporo Japan.
Invited lectures (11) 1. Ashraf Ghanem. “Lipase in organic and analytical chemistry. Annual meeting of the DFG Blaubeuren, Germany, July 2000. 2. Paul Müller and Ashraf
Ghanem. "Asymmetric Cyclopropanation of olefins using a New in situ Generated Phenyliodonium Ylide". Younger European Chemist´s conference: Grenoble, France 2003. 3. Paul
Müller and Ashraf Ghanem. "Rhodium (II)-catalyzed
asymmetric cyclopropanation of olefins". Chemistry day, Champery 2003, Switzerland. 4. Ashraf Ghanem. “Asymmetric cyclopropanation of olefins” University of Tübingen, Germany. Feb. 2004. 5. Ashraf Ghanem, “From Enzymes to Chiral Metal Catalysts: Asymmetric Access to enantiomerically pure/enriched
pharmaceutical building blocks” Second international congress of the pharmaceutical
and drug industries division, 7-9 March 2005, Cairo, Egypt.
6. Ashraf Ghanem, “Towards The
Synthesis of Pharmacologically Active Compounds: Chiral Dirhodium(II) Catalyzed Asymmetric Cyclopropanation of Olefins Using
a New in situ Generated Phenyliodonium Ylides: One Pot Synthesis and Chiral Analysis, Chirality 2005, 11-14 Sept. 2005, Parma, Italy.
7. Ashraf
Ghanem “Asymmetric Access to enantiomerically pure/enriched pharmaceutical building blocks using lipases and
dirhodium (II) catalysts” The 9th International Pharmaceutical Sciences Conferences and Exposition, December
17-21, 2005, Riyadh, Saudi Arabia.
8. Ashraf Ghanem “Biocatalysis in drug development”, Faculty
of Pharmacy, AinShams University, December, 13, 2006, Cairo, Egypt. 9. Ashraf
Ghanem “Lipase-catalyzed kinetic resolution of acidic drugs” Invited lecture, Chirality conference, Geneva 2008. 10. Paul
R. Haddad, Ashraf Ghanem, Hon Wei Boon, Kenneth C. Saunders, Emily F. Hilder” In situ Preparation
of Robust Controlled Porous Modified Sulfopropyl Methacrylate Polymer-based Monolithic Capillary for mHPLC Analysis, ISOPS-9 (the 9th International Symposium on Pharmaceutical Sciences), Ankara-Turkey,
June 2009. 11. Paul R. Haddad,
Ashraf Ghanem, Hon Wei Boon, Kenneth C. Saunders, Emily F. Hilder ”Synthesis and applications
of polymer monoliths for ion-exchange and mixed-mode separations of small molecules” 8th Balaton Symposium on High-Performance Separation Methods, Balaton, Hungary, September
2009. 12. Ashraf
Ghanem “Chiral Square Conformation of N-Naphthaloyl-Tethered Dirhodium
(II) Complex: Structural Basis for Tether Substitution Improving Asymmetric Control in One Pot Cyclopropanation of Olefins”
Molecular Chirality 2010, Sapporo, Japan.
13. Ashraf Ghanem “On the Accurate Determination of the Enantiomeric excesses (ee) in Bio- and Metal-catalyzed
Enantioselective/Asymmetric Reactions” Chirality 2010, Sapporo, Japan.
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